Search results for "Information and Computing Sciences"
showing 10 items of 18 documents
Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems.
2017
Background 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of toxicity is highly dependent on the aryl hydrocarbon receptor (AHR). Binding of TCDD to the AHR leads to changes in transcription of numerous genes. Studies evaluating the transcriptional changes brought on by TCDD may provide valuable insight into the role of the AHR in human health and disease. We therefore compiled a collection of transcriptomic datasets that can be used to aid the scientific community in better understanding the transcriptiona…
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
EVpedia: a community web portal for extracellular vesicles research
2014
Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more tha…
A multimodal retina-iris biometric system using the Levenshtein distance for spatial feature comparison
2020
Abstract The recent developments of information technologies, and the consequent need for access to distributed services and resources, require robust and reliable authentication systems. Biometric systems can guarantee high levels of security and multimodal techniques, which combine two or more biometric traits, warranting constraints that are more stringent during the access phases. This work proposes a novel multimodal biometric system based on iris and retina combination in the spatial domain. The proposed solution follows the alignment and recognition approach commonly adopted in computational linguistics and bioinformatics; in particular, features are extracted separately for iris and…
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
2013
Formation of cilia, microtubule-based structures that function in propulsion and sensation, requires Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT). We have found that, Kif3a is also required to organize centrioles. In the absence of Kif3a, the subdistal appendages of centrioles are disorganized and lack p150(Glued) and Ninein. Consequently, microtubule anchoring, centriole cohesion and basal foot formation are abrogated by loss of Kif3a. Kif3a localizes to the mother centriole and interacts with the Dynactin subunit p150(Glued) . Depletion of p150(Glued) phenocopies the effects of loss of Kif3a, indicating that Kif3a recruitment of p150(Glued) is critical for s…
Neurobiological roots of language in primate audition : common computational properties
2015
Here, we present a new perspective on an old question: how does the neurobiology of human language relate to brain systems in nonhuman primates? We argue that higher-order language combinatorics, including sentence and discourse processing, can be situated in a unified, cross-species dorsal-ventral streams architecture for higher auditory processing, and that the functions of the dorsal and ventral streams in higher-order language processing can be grounded in their respective computational properties in primate audition. This view challenges an assumption, common in the cognitive sciences, that a nonhuman primate model forms an inherently inadequate basis for modeling higher-level language…
sj-docx-2-dhj-10.1177_20552076221074485 - Supplemental material for The role of age and digital competence on the use of online health and social car…
2022
Supplemental material, sj-docx-2-dhj-10.1177_20552076221074485 for The role of age and digital competence on the use of online health and social care services: A cross-sectional population-based survey by T Heponiemi, A-M Kaihlanen, A Kouvonen, L Leemann, S Taipale and K Gluschkoff in Digital Health
sj-docx-1-dhj-10.1177_20552076221074485 - Supplemental material for The role of age and digital competence on the use of online health and social car…
2022
Supplemental material, sj-docx-1-dhj-10.1177_20552076221074485 for The role of age and digital competence on the use of online health and social care services: A cross-sectional population-based survey by T Heponiemi, A-M Kaihlanen, A Kouvonen, L Leemann, S Taipale and K Gluschkoff in Digital Health
sj-docx-2-dhj-10.1177_20552076221074485 - Supplemental material for The role of age and digital competence on the use of online health and social car…
2022
Supplemental material, sj-docx-2-dhj-10.1177_20552076221074485 for The role of age and digital competence on the use of online health and social care services: A cross-sectional population-based survey by T Heponiemi, A-M Kaihlanen, A Kouvonen, L Leemann, S Taipale and K Gluschkoff in Digital Health
sj-docx-1-dhj-10.1177_20552076221074485 - Supplemental material for The role of age and digital competence on the use of online health and social car…
2022
Supplemental material, sj-docx-1-dhj-10.1177_20552076221074485 for The role of age and digital competence on the use of online health and social care services: A cross-sectional population-based survey by T Heponiemi, A-M Kaihlanen, A Kouvonen, L Leemann, S Taipale and K Gluschkoff in Digital Health